85 research outputs found

    P-Glycoprotein Transport of Neurotoxic Pesticides

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    Emotional Competence in Primary School Children: Examining the Effect of a Psycho-Educational Group Intervention: A Pilot Prospective Study

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    Emotional competence (EC) is a key component of children's psychological, cognitive, and social development, and it is a central element of learning. The primary goal of this study was to evaluate the effectiveness of implementing a psycho-educational group intervention aimed at improving children's emotional competence (EC), quality of integration and scholastic skills. A total of 229 children (123 females; M Age = 7.22 years; SD = 0.97 years) completed the Pictures of Facial Affect (POFA), the Drawn Stories Technique, the Classroom Drawing, and the Colored Progressive Matrices. The total sample was randomly divided into an intervention group (N = 116) who took part in psycho-educational activities and a control (no-intervention) group (N = 84). Both groups were tested at baseline, before the intervention started, and at the end of the intervention (4 months from baseline). Results from mixed-model ANOVA revealed a significant main effect for POFA score over time (F = 6.24, p = 0.01) and an interaction effect between POFA and group (F = 4.82, p = 0.03). No significant main effect was found for classroom drawing over time (F = 0.81, p > 0.05) or for quality of integration and group intervention. These findings support the importance of developing psycho-educational programmes in school for promotion of emotional health for preventing not only the onset of problematic behaviours at school such as bullying but also the development of clinical conditions linked to difficulties in emotional recognition, expression, and regulation such as alexithymia

    AMICO galaxy clusters in KiDS-DR3: cosmological constraints from counts and stacked weak-lensing

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    We present a cosmological analysis of abundances and stacked weak-lensing profiles of galaxy clusters, exploiting the AMICO KiDS-DR3 catalogue. The sample consists of 3652 galaxy clusters with intrinsic richness λ20\lambda^*\geq20, over an effective area of 377 deg2^2, in the redshift range z[0.1,0.6]z\in[0.1,\,0.6]. We quantified the purity and completeness of the sample through simulations. The statistical analysis has been performed by simultaneously modelling the comoving number density of galaxy clusters and the scaling relation between the intrinsic richnesses and the cluster masses, assessed through a stacked weak-lensing profile modelling. The fluctuations of the matter background density, caused by super-survey modes, have been taken into account in the likelihood. Assuming a flat Λ\LambdaCDM model, we constrained Ωm\Omega_{\rm m}, σ8\sigma_8, S8σ8(Ωm/0.3)0.5S_8 \equiv \sigma_8(\Omega_{\rm m}/0.3)^{0.5}, and the parameters of the mass-richness scaling relation. We obtained Ωm=0.240.04+0.03\Omega_{\rm m}=0.24^{+0.03}_{-0.04}, σ8=0.860.07+0.07\sigma_8=0.86^{+0.07}_{-0.07}, S8=0.780.04+0.04S_8=0.78^{+0.04}_{-0.04}. The constraint on S8S_8 is consistent within 1σ\sigma with the results from WMAP and Planck. Furthermore, we got constraints on the cluster mass scaling relation in agreement with those obtained from a previous weak-lensing only analysis.Comment: 12 pages, 7 figures, 2 tables. Accepted by A&

    Uridine Metabolism in the Goldfish Retina During Optic Nerve Regeneration: Whole Retina Studies

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    Accumulation of radioactivity from [ 3 H]uridine in incubations of whole goldfish retinas is increased in the ipsilateral retina during a period of regeneration that follows unilateral optic nerve crush. Brief incubations to investigate the nature of enhanced labeling of the acid-soluble fraction showed a peak uptake 4 days following crush, with a gradual decrease to control levels by 21 days following crush. That nucleoside uptake may not mediate the effect is supported by the observation that the rate of uptake of 5′-deoxyadenosine, a nonmetabolizable nucleoside analog, is the same in post-crush (PC) and normal (N) retinal incubations. Following brief incubations of PC and N retinas with [ 3 H]uridine, there is enhanced labeling in PC retinas relative to N retinas of recovered UMP, UDP, UTP, and uridine nucleotide sugars, whereas recovery of labeled uridine itself is slightly decreased. The results suggest that the increased accumulation of radioactivity in PC retinas following incubation with uridine reflects an increase in the activities of retinal uridine kinase and uridine nucleotide kinases.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65630/1/j.1471-4159.1981.tb01713.x.pd

    AMICO galaxy clusters in KiDS-DR3: Cosmological constraints from angular power spectrum and correlation function

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    We study the tomographic clustering properties of the photometric cluster catalogue derived from the Third Data Release of the Kilo Degree Survey, focusing on the angular correlation function and its spherical harmonic counterpart, the angular power spectrum. We measure the angular correlation function and power spectrum from a sample of 5162 clusters, with an intrinsic richness λ15\lambda^*\geq 15, in the photometric redshift range z[0.1,0.6]z\in [0.1, 0.6], comparing our measurements with theoretical models, in the framework of the Λ\Lambda-Cold Dark Matter cosmology. We perform a Monte Carlo Markov Chain analysis to constrain the cosmological parameters Ωm\Omega_{\mathrm{m}}, σ8\sigma_8 and the structure growth parameter S8σ8Ωm/0.3S_8\equiv\sigma_8 \sqrt{\Omega_{\mathrm{m}}/0.3}. We adopt Gaussian priors on the parameters of the mass-richness relation, based on the posterior distributions derived from a previous joint analysis of cluster counts and weak lensing mass measurements carried out with the same catalogue. From the angular correlation function, we obtain Ωm=0.320.04+0.05\Omega_{\mathrm{m}}=0.32^{+0.05}_{-0.04}, σ8=0.770.09+0.13\sigma_8=0.77^{+0.13}_{-0.09} and S8=0.800.06+0.08S_8=0.80^{+0.08}_{-0.06}, in agreement, within 1σ1\sigma, with 3D clustering result based on the same cluster sample and with existing complementary studies on other datasets. For the angular power spectrum, we derive statistically consistent results, in particular Ωm=0.240.04+0.05\Omega_{\mathrm{m}}=0.24^{+0.05}_{-0.04} and S8=0.930.12+0.11S_8=0.93^{+0.11}_{-0.12}, while the constraint on σ8\sigma_8 alone is weaker with respect to the one provided by the angular correlation function, σ8=1.010.17+0.25\sigma_8=1.01^{+0.25}_{-0.17}. Our results show that the 2D clustering from photometric cluster surveys can provide competitive cosmological constraints with respect to the full 3D clustering statistics, and can be successfully applied to ongoing and forthcoming spectro/photometric surveys.Comment: 14 pages, 9 figures. Submitted to Astronomy & Astrophysics (A&A

    Data demonstrating the anti-oxidant role of hemopexin in the heart.

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    The data presented in this article are related to the research article entitled Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress (G. Ingoglia, C. M. Sag, N. Rex, L. De Franceschi, F. Vinchi, J. Cimino, S. Petrillo, S. Wagner, K. Kreitmeier, L. Silengo, F. Altruda, L. S. Maier, E. Hirsch, A. Ghigo and E. Tolosano, 2017) [1]. Data show that heme induces reactive oxygen species (ROS) production in primary cardiomyocytes. H9c2 myoblastic cells treated with heme bound to human Hemopexin (Hx) are protected from heme accumulation and oxidative stress. Similarly, the heme-driven oxidative response is reduced in primary cardiomyocytes treated with Hx-heme compared to heme alone. Our in vivo data show that mouse models of hemolytic disorders, \u3b2-thalassemic mice and phenylhydrazine-treated mice, have low serum Hx associated to enhanced expression of heme- and oxidative stress responsive genes in the heart. Hx mice do not show signs of heart fibrosis or overt inflammation. For interpretation and discussion of these data, refer to the research article referenced above

    Einstein, Planck and Vera Rubin: Relevant Encounters Between the Cosmological and the Quantum Worlds

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    In Cosmology and in Fundamental Physics there is a crucial question like: where the elusive substance that we call Dark Matter is hidden in the Universe and what is it made of? that, even after 40 years from the Vera Rubin seminal discovery [1] does not have a proper answer. Actually, the more we have investigated, the more this issue has become strongly entangled with aspects that go beyond the established Quantum Physics, the Standard Model of Elementary particles and the General Relativity and related to processes like the Inflation, the accelerated expansion of the Universe and High Energy Phenomena around compact objects. Even Quantum Gravity and very exotic Dark Matter particle candidates may play a role in framing the Dark Matter mystery that seems to be accomplice of new unknown Physics. Observations and experiments have clearly indicated that the above phenomenon cannot be considered as already theoretically framed, as hoped for decades. The Special Topic to which this review belongs wants to penetrate this newly realized mystery from different angles, including that of a contamination of different fields of Physics apparently unrelated. We show with the works of this ST that this contamination is able to guide us into the required new Physics. This review wants to provide a good number of these \u201cpaths or contamination\u201d beyond/among the three worlds above; in most of the cases, the results presented here open a direct link with the multi-scale dark matter phenomenon, enlightening some of its important aspects. Also in the remaining cases, possible interesting contacts emerges. Finally, a very complete and accurate bibliography is provided to help the reader in navigating all these issues

    Uridine Metabolism in the Goldfish Retina During Optic Nerve Regeneration: Cell-Free Preparations

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    The activities of uridine kinase (EC 2.7.1.48), uridine monophosphate (UMP) kinase (EC 2.7.1.3.14), and uridine diphosphate (UDP) kinase (EC 2.7.4.6) were measured in retinal high-speed supernatant fractions following unilateral optic nerve crush in the goldfish. The enzyme activities followed a similar time course, with initial increases 2-3 days following nerve crush, peak activity at 4 days, and a gradual return to basal levels by day 21. The magnitude of the stimulation on day 4 was about 35% in each case. Activities of two enzymes of intermediary metabolism, pyruvate kinase (EC 2.7.1.40) and lactic dehydrogenase (EC 1.1.1.27), were not altered, indicating that the coordinate increases in nucleoside and nucleotide kinase activities were specific responses to the nerve injury. The increased labeling could not be explained by altered phosphohydrolytic activities. The nature of the enhancement was further studied in UDP kinase, the most active of the kinases examined. Neither low-molecular-weight components nor substrate availability could account for the observed increase in UDP kinase in the 4 day post-crush retinas. The K m , for UDP was unaltered, and a mixing experiment did not support the possibility that stimulatory or inhibitory factors played a role. The enhancement of UDP kinase activity was blocked by injection of actinomycin D following nerve crush. The results suggest that the observed increases in enzymes of uridine metabolism result from their increased formation following nerve crush.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65504/1/j.1471-4159.1981.tb01714.x.pd

    Euclid preparation. XXXII. Evaluating the weak lensing cluster mass biases using the Three Hundred Project hydrodynamical simulations

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    The photometric catalogue of galaxy clusters extracted from ESA Euclid data is expected to be very competitive for cosmological studies. Using state-of-the-art hydrodynamical simulations, we present systematic analyses simulating the expected weak lensing profiles from clusters in a variety of dynamic states and at wide range of redshifts. In order to derive cluster masses, we use a model consistent with the implementation within the Euclid Consortium of the dedicated processing function and find that, when jointly modelling mass and the concentration parameter of the Navarro-Frenk-White halo profile, the weak lensing masses tend to be, on average, biased low by 5-10% with respect to the true mass, up to z=0.5. Using a fixed value for the concentration c200=3c_{200} = 3, the mass bias is diminished below 5%, up to z=0.7, along with its relative uncertainty. Simulating the weak lensing signal by projecting along the directions of the axes of the moment of inertia tensor ellipsoid, we find that orientation matters: when clusters are oriented along the major axis, the lensing signal is boosted, and the recovered weak lensing mass is correspondingly overestimated. Typically, the weak lensing mass bias of individual clusters is modulated by the weak lensing signal-to-noise ratio, related to the redshift evolution of the number of galaxies used for weak lensing measurements: the negative mass bias tends to be larger toward higher redshifts. However, when we use a fixed value of the concentration parameter, the redshift evolution trend is reduced. These results provide a solid basis for the weak-lensing mass calibration required by the cosmological application of future cluster surveys from Euclid and Rubin
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